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Titel och upphov Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders
Utgivning, distribution etc. Department of Clinical and Experimental Medicine, Linköping University, Linköping : 2017
Fysisk beskrivning
Serietitel - ej biuppslagsform Linköping University medical dissertations, ISSN 0345-0082 ; 1579
Anmärkning: Allmän
Anmärkning: Dissertation o.dyl. Diss. (sammanfattning) Linköping : Linköpings universitet, 2017
Anmärkning: Innehållsbeskrivning, sammanfattning Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. There are only a few currently available treatments with narrow efficacy and variable patient response. Thus it is important to find new, more effective medications to increase the number of patients who can benefit from pharmacological treatment of AUD. The research presented in this thesis work focuses on the critical involvement of central neuropeptides in alcohol-related behaviors. The overall aim was to evaluate the nociceptin/orphanin FQ (NOP) receptor, the neuropeptide Y (NPY) Y2 receptor and the melanin-concentrating hormone (MCH) receptor 1 as novel and potential pharmacological treatment targets for AUD by testing the NOP receptor agonist SR-8993, the NPY-Y2 receptor antagonist CYM-9840 and the MCH1 receptor antagonist GW803430 in established animal models. (From the abstract)
Anmärkning: Språk Med populärvetenskaplig sammanfattning på svenska
Term
Indexterm - Okontrollerad
Institutionsnamn Linköpings universitet Institutionen för klinisk och experimentell medicin Utgivare
ISBN
*00002175cam 122004097a 4500
*00129101
*00520171109084922.0
*008170822s2017 sw |||| m 00| ||eng c
*020 $a978-91-7685-484-6
*035 $a(DiVA)urn:nbn:se:liu:diva-139884
*035 $a(SE-LIBR)21149221
*0410 $aeng$bswe
*08204$a616.861061$223/swe
*084 $aVlna$2kssb/8 (machine generated)
*1001 $aAziz, Abdul Maruf Asif,$d1987-$4aut$0404985
*24510$aNeuropeptide Receptors as Treatment Targets in Alcohol Use Disorders /$cAbdul Maruf Asif Aziz
*260 $aLinköping :$bDepartment of Clinical and Experimental Medicine, Linköping University,$c2017
*300 $a102 s. :$bill
*4901 $aLinköping University medical dissertations,$x0345-0082 ;$v1579
*500 $aHärtill 4 uppsatser
*502 $aDiss. (sammanfattning) Linköping : Linköpings universitet, 2017
*5201 $aAlcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. There are only a few currently available treatments with narrow efficacy and variable patient response. Thus it is important to find new, more effective medications to increase the number of patients who can benefit from pharmacological treatment of AUD. The research presented in this thesis work focuses on the critical involvement of central neuropeptides in alcohol-related behaviors. The overall aim was to evaluate the nociceptin/orphanin FQ (NOP) receptor, the neuropeptide Y (NPY) Y2 receptor and the melanin-concentrating hormone (MCH) receptor 1 as novel and potential pharmacological treatment targets for AUD by testing the NOP receptor agonist SR-8993, the NPY-Y2 receptor antagonist CYM-9840 and the MCH1 receptor antagonist GW803430 in established animal models. (From the abstract)
*546 $aMed populärvetenskaplig sammanfattning på svenska
*650 4$aAlcoholism
*650 4$aDrug therapy
*650 4$aReceptors, neuropeptide
*653 $aAlkoholism
*653 $aLäkemedelsterapi
*653 $aReceptorer, neuropeptid
*71012$aLinköpings universitet$bInstitutionen för klinisk och experimentell medicin$4pbl$0347333
*830 0$aLinköping University Medical Dissertations,$x0345-0082 ;$v1579
*852 $hDiss.513
*85642$uhttp://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139884$zSammanfattning och ramberättelse från Linköping University Electronic Press
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