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Titel och upphov Psychoactive prescription drug use disorders, misuse and abuse : pharmacoepidemiological aspects
Utgivning, distribution etc. Department of Medical and Health Sciences, Linköping University, Linköping : 2016
Fysisk beskrivning 121 including Appendix s. : ill.
Serietitel - ej biuppslagsform Linköping University medical dissertations, ISSN 0345-0082 ; 1521
Anmärkning: Allmän
Anmärkning: Dissertation o.dyl. Diss. (sammanfattning) Linköping : Linköpings universitet, 2016
Anmärkning: Innehållsbeskrivning, sammanfattning Psychoactive prescription drugs are common and important interventions in the treatment of mental disorders, pain and other diseases, but their use is associated with a risk of drug use disorder, misuse and abuse. Today, these are globally recognised and emerging public health concerns. However, important information on the extent of these problems, their characteristics and important risk factors is lacking. The aim of this thesis is to estimate the prevalence of psychoactive prescription drug use disorders, misuse and abuse, and to investigate the association with some potential risk factors. The thesis is based on data from national registers on forensic pathology and toxicology investigations, spontaneously reported adverse drug reactions, and dispensed prescription drugs. Fatal unintentional intoxications with tramadol were described. Spontaneously reported cases on tramadol dependence were summarised. Non-prescribed use of tramadol, diazepam, flunitrazepam, zolpidem and zopiclone was investigated in drug-impaired drivers and the association with patient factors was assessed. Longitudinal utilisation patterns of pregabalin were analysed in relation to the maximum approved daily dose of the drug, and the association with patient factors was evaluated. The findings show that psychoactive prescription drugs use disorders, misuse and abuse occur across groups in the population. The high prevalence in some subgroups and the considerable adverse outcomes demonstrate that this is a significant clinical and public health concern. The findings suggest a potential for improvements in the utilisation of psychoactive prescription drugs. The results may be useful in the planning of clinical and regulatory preventive interventions to promote the individualised, rational and safe use of such drugs. (From the cover)
Anmärkning: Språk Med sammanfattning på svenska
Term
Indexterm - Okontrollerad
Institutionsnamn Linköpings universitet. Institutionen för medicin och hälsa Utgivare
ISBN
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*00128773
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*008160824s2016 sw |||| m 00| ||eng c
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*1001 $aTjäderborn, Micaela,$d1983-$0397476
*24510$aPsychoactive prescription drug use disorders, misuse and abuse : $bpharmacoepidemiological aspects / $cMicaela Tjäderborn
*260 $aLinköping : $bDepartment of Medical and Health Sciences, Linköping University,$c2016
*300 $a121 including Appendix s. : $bill.
*4901 $aLinköping University medical dissertations,$x0345-0082 ;$v1521
*500 $aHärtill 4 uppsatser
*502 $aDiss. (sammanfattning) Linköping : Linköpings universitet, 2016
*5208 $aPsychoactive prescription drugs are common and important interventions in the treatment of mental disorders, pain and other diseases, but their use is associated with a risk of drug use disorder, misuse and abuse. Today, these are globally recognised and emerging public health concerns. However, important information on the extent of these problems, their characteristics and important risk factors is lacking. The aim of this thesis is to estimate the prevalence of psychoactive prescription drug use disorders, misuse and abuse, and to investigate the association with some potential risk factors. The thesis is based on data from national registers on forensic pathology and toxicology investigations, spontaneously reported adverse drug reactions, and dispensed prescription drugs. Fatal unintentional intoxications with tramadol were described. Spontaneously reported cases on tramadol dependence were summarised. Non-prescribed use of tramadol, diazepam, flunitrazepam, zolpidem and zopiclone was investigated in drug-impaired drivers and the association with patient factors was assessed. Longitudinal utilisation patterns of pregabalin were analysed in relation to the maximum approved daily dose of the drug, and the association with patient factors was evaluated. The findings show that psychoactive prescription drugs use disorders, misuse and abuse occur across groups in the population. The high prevalence in some subgroups and the considerable adverse outcomes demonstrate that this is a significant clinical and public health concern. The findings suggest a potential for improvements in the utilisation of psychoactive prescription drugs. The results may be useful in the planning of clinical and regulatory preventive interventions to promote the individualised, rational and safe use of such drugs. (From the cover)
*546 $aMed sammanfattning på svenska
*650 4$aAccidents
*650 4$aAnalgesics, opioid
*650 4$aOpioid-related disorders
*650 4$aPrescription drug diversion
*650 4$aDriving under influence
*653 $aReceptbelagda läkemedel, olaglig handel
*653 $aOlyckor
*653 $aSmärtstillande medel, opioider
*653 $aNarkotikamissbruk
*653 $aKörning under påverkan
*7102 $aLinköpings universitet.$bInstitutionen för medicin och hälsa$4pbl $0308697
*830 0$aLinköping University Medical Dissertations, $x0345-0082 ; $v1521
*852 $hDiss.495
*85642$uhttp://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130768 $zSammanfattning och ramberättelse från Linköping University Electronic Press
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