CAN:s bibliotek

*00001544cam 122004097a 4500
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*00520111025104623.0
*007cr |||||||||||
*008111011s2011    sw a   esm    000 0 eng c
*020  $a978-91-7457-464-7
*035  $a(SE-LIBR)12325553$x12325553
*1001 $aHenriksson, Richard,$d1981-
*24510$aMolecular mechanisms underlying increased PDYN and dynorphin expression in the prefrontal cortex of alcoholic men$h[Elektronisk resurs] /$cRichard Henriksson
*256  $aText
*260  $aStockholm,$c2011
*300  $a27 s.
*500  $aHärtill 3 uppsatser
*502  $aDiss. (sammanfattning) Stockholm : Karolinska institutet, 2011
*5208 $aAlcohol dependence is a chronic relapsing disorder caused by drug x gene x environment interactions for which pharmacotherapy is but moderately effective. The prefrontal cortex is a brain region important for cognitive control / behavioral flexibility which function is impaired in alcoholics. Although the exact role of the dynorphin / κ-opioid receptor system in alcohol dependence is unknown, it has been suggested to contribute to the psychopathology of this disorder. Consistently, prodynorphin gene and dynorphin peptide expression is increased in the prefrontal cortex of alcoholic men. The aim of this thesis was to identify molecular mechanisms underlying these alterations. (From the abstract)
*538  $aPDF
*650 4$aAlcoholism
*650 4$aPrefrontal cortex
*650 4$aDynorphins
*650 4$aEnkephalins
*650 4$aMale
*653  $aDynorfiner
*653  $aAlkoholism
*653  $aPrefrontal kortex
*653  $aEnkefaliner
*653  $aMän
*852  $hDiss.448
*856  $uhttp://hdl.handle.net/10616/40752$zOnline
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