CAN:s bibliotek

*00001759cam 122004457a 4500
*00126722
*00520090924074625.0
*008090904s2009    sw a   e m   |000 0 eng c
*020  $a978-91-7409-594-4$x978-91-7409-594-4
*035  $a(SE-LIBR)11589581$x11589581
*0410 $aeng$bswe
*1001 $aHäggkvist, Jenny,$d1977-
*24510$aBrain opioid mechanisms in amphetamine induced behaviours /$cJenny Häggkvist
*260  $aStockholm :$bKarolinska institutet,$c2009$y2009
*300  $a52 s :$bdiagr., tab.
*500  $aHärtill 4 uppsatser
*502  $aDiss. (sammanfattning) Stockholm : Karolinska institutet, 2009
*5208 $aAmphetamine abuse and dependence are global health problems, affecting large numbers of individuals. Despite extensive research efforts, there has been no evidence-based pharmacotherapy available for amphetamine dependence. However, recent clinical trials have suggested that the opioid receptor antagonist naltrexone reduces drug consumption and craving in amphetamine dependent paients. To further elucidate the interaction between amphetamine and the endogenous opioid system, the present thesis investigated the effect of naltrexone on amphetamine-induced behaviours in the rat. In addition, the effect of naltrexone on specific amphetamine-induced changes in brain neurochemistry, i.e. dopamine release in the striatum, was investigated using both in vivo microdialysis in animals as well as PET imaging in humans. (From the abstarct)
*546  $aMed sammanfattning på svenska
*650 4$aAmphetamine
*650 4$aNaltrexone
*650 4$aPharmacology
*650 4$aNarcotic antagonists
*650 4$aReceptors, opioid
*653  $aAmfetamin
*653  $aNaltrexon
*653  $aFarmakologi
*653  $aNarkotikablockerare
*653  $aOpioidreceptorer
*77608$iÄven utgiven elektroniskt$aHäggkvist, Jenny$d2009$tBrain opioid mechanisms in amphetamine induced behaviours$w11589603
*852  $hDiss.418
*8564 $uhttp://diss.kib.ki.se/2009/978-91-7409-594-4/thesis.pdf$zFulltext$galias: URL
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