CAN:s bibliotek

*000      am
*00113114
*008070120s2006||||sw|||||e|m||||||||0|eng|d
*020  $a91-85481-99-8
*1001 $aJohansson, Björn Axel,$d1959-
*24510$aBenzodiazepine and opioid dependence :$bclinical and meta-analytical studies / $cBjörn Axel Johansson
*260  $aLund :$bLund University, Faculty of Medicine,$c2006
*300  $a69 s :$bill.
*440  $aLund University, Faculty of Medicine Doctoral dissertation series,$x1652-8220 ;$v2006:74
*520  $aIn the BZD (benzodiazepine) taper study (Paper l) 21 BZD dependent (DSM-lV) patients were included for a 10-day inpatient detoxification. In the dependence rate study (Paper ll) the frequency of prescribed drug dependence among 130 alcohol dependent patients in open care, 23 long-term institutionalized alcoholics, and 120 healthy controls were analysed. Common for the third and forth paper was the meta-analytical technique. In the methadone study (Paper lll) 8 RCT (randomised controlled trial) were included with 1,511 patients. In the naltrexone review (Paper lV) 15 RCT were included with 990 patients. In the methadone study retention in treatment was higher (d=0.90), and opioid abuse and criminality was lower (d=0.61) and (d=0.35) respectively compared to controlled conditions. In the naltrexone review naltrexone was significantly better than controlled conditions in reducing the number of opioid positive urines (d=0.44). (From the abstract)
*650 4$aOpioid-related disorders
*650 4$aBenzodiazepines
*650 4$aMeta-analysis
*650 4$aMethadone
*650 4$aNaltrexone
*653  $aOpiatmissbruk
*653  $aBensodiazepiner
*852  $hDiss.373
*8564 $uhttps://lucris.lub.lu.se/ws/files/4438298/546759.pdf$zFulltext
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