CAN:s bibliotek

*000      am
*00118731
*008070120|1991|||||||||||e|m||||||||0|eng|d
*020  $a91-554-2708-1$x91-554-2708-1
*1001 $aGerdin, Eva
*24510$aMorphine and pregnancy :$baspects of the use of morphine and morphine-related compounds
*260  $aUppsala :$bUniv,$c1991$y1991
*300  $a48 s :$bill.
*440 0$aComprehensive summaries of Uppsala dissertations from the Faculty of Medicine ;$v293
*500  $aHärtill 6 uppsatser
*520  $aThe use of obstetric analgesia was investigated in 335 207 women delivered vaginally between 1983-1986. In almost half of all women a systemic opioid, morphine or pethidine, was given during labour. Morphine was eliminated more rapidly in parturients than in non-pregnant women, probably because of increased metabolism of morphine during labour. In most of the neonates no morphine was detected in the plasma at delivery. The transplacental transport of morphine in humans was rapid and the foetal plasma concentrations were close to those of the mother during the two hours after administration of the dose. Thus, the intrauterine exposure of the foetus to morphine is short and only small residual amounts of morphine are left to be metabolized by the neonate after birth.
*650 4$aMorphine
*650 4$aAnalgesia, obstetrical
*650 4$aAnalgesia, epidural
*650 4$aLabor
*650 4$aPregnancy
*650 4$aPharmacokinetics
*650 4$aFemale
*650 4$aMeperidine
*650 4$aDelivery
*650 4$aInfant, newborn
*650 4$aMetabolism
*653  $aMorfin
*653  $aBedövningsmedel
*653  $aGraviditet
*653  $aKvinnor
*653  $aNyfödda
*852  $hDiss.132
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