Titel och upphov First pass-metabolism of alcohol and its clinical significance. (Första passage-metabolism av alkohol och dess kliniska betydelse.) (Swe).
Anmärkning: Innehållsbeskrivning, sammanfattning The metabolism of alcohol also proceeds in other parts of the body as well as the liver. Some part of the alcohol consumed by mouth is metabolized chiefly through the alcohol dehydrogenase (ADH) activity in the gastric membrane before it is taken up into the bloodstream. This significant first pass-metabolism of alcohol, particularly on a full stomach, protects the organism against high concentration of alcohol. The first pass-metabolism is lower in women than in men. It is low in alcoholics too, presumably because of alcohol-related damage to the gastric membrane. Several drugs in common use reduce the ADH activity in the gastric membrane, a point it may be well to remember when treating patients who use alcohol. (Summary)
Term
Indexterm - Okontrollerad
Okontrollerad titel Första passage-metabolism av alkohol och dess kliniska betydelse. (Swe)
Värdpublikation Nordisk medicin ISSN 0029-1420 106(1991):12, 325-327
*000 ab a ar
*00118515
*008070120s1991||||sw|||||e||||||||||||swe||
*1001 $aRoine, Risto
*24510$aFirst pass-metabolism of alcohol and its clinical significance. (Första passage-metabolism av alkohol och dess kliniska betydelse.) (Swe).
*520 $aThe metabolism of alcohol also proceeds in other parts of the body as well as the liver. Some part of the alcohol consumed by mouth is metabolized chiefly through the alcohol dehydrogenase (ADH) activity in the gastric membrane before it is taken up into the bloodstream. This significant first pass-metabolism of alcohol, particularly on a full stomach, protects the organism against high concentration of alcohol. The first pass-metabolism is lower in women than in men. It is low in alcoholics too, presumably because of alcohol-related damage to the gastric membrane. Several drugs in common use reduce the ADH activity in the gastric membrane, a point it may be well to remember when treating patients who use alcohol. (Summary)
*650 4$aAlcohol, ethyl
*650 4$aAlcohol dehydrogenase
*650 4$aDrug interactions
*650 4$aDrugs
*650 4$aMetabolism
*650 4$aAspirin
*650 4$aAcetaminophen
*653 $aAlkohol
*653 $aMetabolism
*653 $aLäkemedel
*7400 $aFörsta passage-metabolism av alkohol och dess kliniska betydelse. (Swe)
*7730 $tNordisk medicin$x0029-1420$g106(1991):12, 325-327
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