CAN:s bibliotek

*000      am
*00118069
*008070120s1992||||sw|||||e|m||||||||0|eng|d
*020  $a91-628-0682-3
*1001 $aHasselström, Jan,$d1955-$0358667
*24510$aOn the kinetics, metabolism and effects of morphine, codeine and their metabolites.
*260  $aStockholm,$c1992
*300  $a63 s :$bill.
*500  $aDiss. (sammanfattning) Stockholm : Karol. inst. - Härtill sju uppsatser
*520  $aMorphine was administered to healthy volunteers, cancer patients and patients with liver cirrhosis. Morphine was highly extracted and showed small inter-individual variability in distribution and elimination indices in healthy volunteers. Severe liver cirrhosis caused a decrease in systemic plasma clearance of morphine by more than 50 percent, as well as an increased oral bioavailability to almost 100 percent. This was reflected in doubled AUCs of morphine after i.v. administration and up to five-fold higher levels after oral doses as compared to those seen in individuals with normal hepatic function. In spite of a lower metabolism of morphine, metabolite levels were higher in patients with liver cirrhosis, due to a decreased rate of renal excretion. A single dose of codeine administered orally to poor or extensive metabolizers of debrisoquine prolonged the oro-ceacal transit time, determined by the lactulose hydrogen breath test, to the same extent. This indicates that the O-demethylated metabolites of codeine play an insignificant role in this important opioid effect of codeine, in contrast to what has been shown for analgesia.
*650 4$aMorphine
*650 4$aCodeine
*650 4$aKinetics
*650 4$aMetabolism
*650 4$aNarcotics
*650 4$aAnimal
*650 4$aMale
*650 4$aFemale
*650 4$aLiver cirrhosis
*650 4$aRats
*650 4$aUrine
*650 4$aPlasma
*653  $aMorfin
*653  $aNarkotika
*653  $aDjurförsök
*653  $aMän
*653  $aKvinnor
*653  $aLevercirrhos
*852  $hDiss.159
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