CAN:s bibliotek

*000      am
*00117797
*008070120|1993|||||||||||e|m||||||||0|eng|d
*020  $a951-8913-55-2$x951-8913-55-2
*1001 $aHyytiä, Petri
*24510$aAlcohol reinforcement :$bgenetic differences and attenuation by opioid antagonists
*260  $aHelsinki,$c1993$y1993
*300  $a73 s.
*500  $aDiss. (sammanfattning) Helsingfors : Univ. - Härtill 6 uppsatser
*520  $aThe present studies were desigend to first compare alcohol-seeking behavior of the alcohol-preferring AA and heterogenous Wistar rats in an operant conditioning situation. Consumption of oral etonitazene and cocaine by The AAs, ANAs, and Wistars was also studied. The final experiments investigated the effect of opioid antagonists on alcohol self-administration by the AA rats. Together, the results suggest that alcohol drinking is a learned response, reinforced by central effects of ethanol. This reinforcement is under genetic control, and appears, at least partially, to be mediated by the endogenous opioid system, with mu-receptors playing the dominant role in the AA rats.
*650 4$aReceptors, opioid, mu
*650 4$aAnimal
*650 4$aRats
*650 4$aEtonitazene
*650 4$aCocaine
*650 4$aNarcotic antagonists
*650 4$aAlcohol, ethyl
*650 4$aReinforcement (psychology)
*650 4$aTaste
*650 4$aGenetics
*650 4$aNaloxone
*653  $aDjurförsök
*653  $aReceptorer
*653  $aKokain
*653  $aAntagonister
*653  $aNarkotika
*653  $aAlkohol
*653  $aGenetik
*852  $hDiss.172
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