CAN:s bibliotek

*000      am
*00117649
*008070120|1993|||||||||||e||||||1|||0|eng|d
*020  $a0-306-44583-2$x0-306-44583-2
*24510$aAlcohol, cell membranes, and signal transduction in brain.
*260  $aNew York :$bPlenum Press,$ccop. 1993$y1993
*300  $a320 s :$bill.
*500  $aProceedings of the Marcus Wallenberg Symposium on Alcohol, Cell Membranes, and Signal Transduction in Brain, held June 28-July 1, 1993, in Lund, Sweden
*520  $aThe book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels. The third section on second messengers includes chapters on ethanol effects on nucleoside transport and the induction of heterologous desensitation, G-proteins, phospholipases generating second messengers, and discussion on the selectivity of ethanol actions at different levels of the signal transduction. Chapters in the fourth section on gene expression describe the regulation of neuronal gene transcription by ethanol and the effects of acute and chronic administration of ethanol on c-fos expression. The organization of the book follows the effects of ethanol from actions on membrane lipids, ion channels and, followed by effects on signal transduction and intracellular proteins to the regulation of the genes.
*650 4$aSignal transduction
*650 4$aCongresses
*650 4$aAlcohol, ethyl
*650 4$aPhysiology
*650 4$aCell membrane
*650 4$aBrain
*650 4$aReceptors, N-methyl-D-aspartate
*650 4$aAnimal
*650 4$aIon channels
*650 4$aSecond messenger systems
*650 4$aPhosphotransferases
*650 4$aGene expression
*653  $aAlkohol
*653  $aHjärnan
*653  $aDjurförsök
*653  $aFysiologi
*653  $aMembraner
*653  $aReceptorer
*7001 $aAlling, Christer$eed. et al
*7111 $aMarcus Wallenberg Symposium on Alcohol, Cell Membranes, and Signal Transduction in Brain$c(Lund :$d1993)
*852  $h4b87
^