Hylla
Titel och upphov Studies on morphine and its main metabolites in man and rat, with special reference to some non-analgesic effects and pharmacokinetics after different routes of administration.
Utgivning, distribution etc.
Fysisk beskrivning
Anmärkning: Allmän Med sammanfattning på svenska. - Diss. (sammanfattning) Lund : Univ. - Härtill 7 uppsatser
Anmärkning: Innehållsbeskrivning, sammanfattning A sensitive and specific gas chromatographic mass spectrometric (GC-MS) method for analysis of morphine was developed. Plasma concentrations of morphine were analysed in women and children after rectal administration of the drug. Plasma concentrations of morphine metabolites (M3G and M6G) were analysed by HPLC after iv, oral and transdermal administration of morphine to healthy volunteers. The relationship between plasma concentrations of morphine, M3G and M6G and some non-analgesic effects of morphine were studied after iv, oral and transdermal administration. The relationship between dose and urodynamic effects of intrathecal administration of morphine, M3G and M6G were studied in unanaesthetized rats.
Term
Indexterm - Okontrollerad
ISBN
*000 am
*00117159
*008070120|1993|||||||||||e|m||||||||0|eng|d
*020 $a91-628-0927-X$x91-628-0927-X
*1001 $aWesterling, Dagmar
*24510$aStudies on morphine and its main metabolites in man and rat, with special reference to some non-analgesic effects and pharmacokinetics after different routes of administration.
*260 $aLund,$c1993$y1993
*300 $a73 s :$bill.
*500 $aMed sammanfattning på svenska. - Diss. (sammanfattning) Lund : Univ. - Härtill 7 uppsatser
*520 $aA sensitive and specific gas chromatographic mass spectrometric (GC-MS) method for analysis of morphine was developed. Plasma concentrations of morphine were analysed in women and children after rectal administration of the drug. Plasma concentrations of morphine metabolites (M3G and M6G) were analysed by HPLC after iv, oral and transdermal administration of morphine to healthy volunteers. The relationship between plasma concentrations of morphine, M3G and M6G and some non-analgesic effects of morphine were studied after iv, oral and transdermal administration. The relationship between dose and urodynamic effects of intrathecal administration of morphine, M3G and M6G were studied in unanaesthetized rats.
*650 4$aBiological availability
*650 4$aMorphine
*650 4$aNarcotics
*650 4$aPharmacokinetics
*650 4$aMetabolism
*653 $aMorfin
*653 $aNarkotika
*852 $hDiss.197
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